Welcome to the Zhu Lab at NUS
We crack the code of nature-designed biomolecules with state-of-the-art chemistry for next-generation therapeutics and catalysis to improve human health and life quality
Next-Generation RNA Therapeutics
We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR.
Reprogram RNA with Small-Molecule
We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo.
Enzyme-Like DNA Catalyst Design
We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.
Contact
Dr. Ru-Yi Zhu (rzhu@nus.edu.sg)
S9-12-01G
Department of Chemistry
National University of Singapore
Positions Available
We are recruiting talented and self-motivated graduate students, FYP, and UROPS students. Candidates with synthetic chemistry, medicinal chemistry, chemical biology, and molecular biology backgrounds are encouraged to apply.
The views and opinions expressed herein are those of the author(s) and do not represent the views and opinions of the National University of Singapore or any of its subsidiaries or affiliates
The Zhu Lab 